PLATON aims to provide patients suffering from different types of gastrointestinal cancers the best available scientifically founded, biomarker-based therapy tailored to the individual needs of the patient. The framework is designed as:
- Multicentre, prospective, observational, umbrella study
- Biobanking
- Platform-design with associated sub-studies
- Open number of participants and study sites
PLATON’s study design provides clincial researchers the possibilties to:
- Browse on cases, cancer types, mutations and clinical trials within the network to match individual molecular profiles to therapy options and clinical trials
- Discuss therapy options with other medical professionals
- Assess the frequency of targetable mutations (incl. TMB and MSI status) in different disease groups
- Analyse the number of patients receiving therapies based on their genomic profile
- Evaluate the differences between FFPE specimen vs. cfDNA acc. targetable alterations (pilot phase)
- Analyse the overall survival (OS) acc. to the molecular profile
- Establish a data and sample collection